Here are Pixie's default hotkeys and what they do. You can easily customize them. If you play EQ2 then you don't have to use hotkeys because you can just click on the toolbar if you set it to stay on top. If you play EQ1 then you really need to know the toolbar hotkey. The hotkeys marked by an * are for those who want to multi-box (play multiple characters at once).
To customize the hotkeys press on the Main Control and then select Hotkeys in the list on the left. You will then see the page below. Simply click on the hotkey you want to change and press the new key combination for it. Press to restore all the hotkeys to the defaults listed above. While this option page is open the hotkeys will not function.